![]() ![]() ![]() The experimental results indicate that qDIC-PCM is superior to qZ-PCM in quantitative phase imaging of samples with certain scattering, while qZ-PCM has higher spatial resolution than qDIC-PCM. ![]() Both imaging modalities have the merits of high stability and low coherent noise due to their common path interference structure and partially coherent illumination. Both imaging modalities are realized through spatial light modulator (SLM) based pupil phase modulation, and switching between the two imaging modes is performed by rotating two polarizers. In this study, we propose a dual-modality quantitative phase contrast microscopic (DQPCM) platform that integrates quantitative differential interference phase-contrast microscopy (qDIC-PCM) and quantitative Zernike phase-contrast microscopy (qZ-PCM) in the same microscopy. Phase-contrast optical microscopy that converts phase modulation of transparent samples into intensity modulation plays an indispensable role in biomedical research. ![]()
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